What is Amelogenesis imperfects (AI) ?

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Admin_NHT Staff asked 5 years ago
  • It is a congenital disorder of tooth development caused by the mutations in the AMELX, ENAM, MMP20, KLK-4, FAM83H, WDR72, LAMB3 and ITGB6 genes.
  • These genes encode for the proteins ameloblastin, enamelin, tuftelin and amelogenin that are responsible for the development and maintenance of the enamel.
  • Symptoms :
    • Discolored, unusually small, pitted or grooved teeth
    • Enamel hypoplasia
    • Increased risk of dental cavities
    • Teeth are more sensitive to temperature changes
    • Gingival hyperplasia
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